Role of Epithelial-Endothelial Cell Interaction in the Pathogenesis of SARS-CoV-2 Infection

Dr Michael Chan and Dr. Kenrie Hui just published for Oxford University Press in Clinical Infectious Diseases about the role of epithelial-endothelial cell interaction in the pathogenesis of SARS-CoV-2 infection.

After exploring the cytokine and chemokine production after SARS-CoV-2 infection with well-differentiated human airway epithelial cells, they measured the susceptibility to infection, immune response, and expression of adhesion molecules, in human pulmonary microvascular endothelial cells (HPMVECs) exposed to conditioned medium from infected epithelial cells.


This study evaluates the role of endothelial cells in the development of clinical disease caused by SARS-CoV-2, and the importance of endothelial cell-epithelial cell interaction in the pathogenesis of human COVID-19 diseases.

Learn more about Michal Chan and Kenrie Hui's projects on this page.

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